Immunoassay for HIV Drug Metabolites Tenofovir and Tenofovir Diphosphate
نویسندگان
چکیده
منابع مشابه
Population pharmacokinetics of tenofovir and tenofovir‐diphosphate in healthy women
The objective of this analysis was to develop and qualify a population pharmacokinetic model describing plasma tenofovir (TFV) concentrations and tenofovir-diphosphate (TFV-DP) concentrations in peripheral blood mononuclear cell (PBMC) in healthy women volunteers from the MTN-001 clinical trial, an open label 3-way crossover study of oral tenofovir disoproxil fumarate 300 mg tablet, TFV 1% vagi...
متن کاملPlasma Tenofovir, Emtricitabine, and Rilpivirine and Intracellular Tenofovir Diphosphate and Emtricitabine Triphosphate Pharmacokinetics following Drug Intake Cessation.
Pharmacokinetic (PK) data describing a prolonged time course of antiretrovirals in plasma and peripheral blood mononuclear cells (PBMCs) are important for understanding and managing late or missed doses and to assess the appropriateness of compounds for preexposure prophylaxis (PrEP). This study aimed to evaluate the PK of coformulated tenofovir disoproxil fumarate (DF), emtricitabine, and rilp...
متن کاملA drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.
INTRODUCTION More than a million people acquire HIV infection annually. Pre-exposure prophylaxis (PrEP) using antiretrovirals is currently being investigated for HIV prevention. Oral and topical formulations of tenofovir have undergone preclinical and clinical testing to assess acceptability, safety and effectiveness in preventing HIV infection. AREAS COVERED The tenofovir drug development pa...
متن کاملEmtricitabine/tenofovir (Truvada) for HIV prophylaxis.
Few severe adverse effects were associated with the use of emtricitabine/tenofovir in studies of preexposure prophylaxis.2-4 The drug must not be prescribed if the patient’s creatinine clearance is less than 60 mL per minute per 1.73 m2 (1.00 mL per second per m2) because its use has been associated with renal failure and Fanconi syndrome.5 Although rare and not reported in premarketing studies...
متن کاملIntracellular tenofovir-diphosphate accumulation in an HIV-infected patient with Fanconi syndrome and osteomalacia
We present a patient with tenofovir disoproxil fumarate (TDF)-induced Fanconi syndrome, osteomalacia and concurrent nucleos(t)ide reverse transcriptase inhibitor related CD4 cell decline. Sequentially measured intracellular (ic) tenofovir-diphosphate (TFV-DP) levels were extremely high, with plasma TFV just slightly elevated. In June 2008 a 53-year-old Caucasian male complained of severe pain i...
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ژورنال
عنوان ژورنال: ACS Infectious Diseases
سال: 2020
ISSN: 2373-8227,2373-8227
DOI: 10.1021/acsinfecdis.0c00010